منابع مشابه
Mitophagy Regulated by the PINK1-Parkin Pathway
Mitochondria play key roles in the cellular metabolism of lipids and iron as well as in cell death signaling. Mitochondrial dysregulation produces reactive oxygen species (ROS), which results in oxidative stress. Moreover, the accumulation of damaged mi‐ tochondria leads to cell death and tissue dysfunction. Mitochondrial maintenance in‐ volves mitophagy, a selective autophagy process that remo...
متن کاملMitophagy and Parkinson's disease: The PINK1–parkin link☆
The study of rare, inherited mutations underlying familial forms of Parkinson's disease has provided insight into the molecular mechanisms of disease pathogenesis. Mutations in these genes have been functionally linked to several key molecular pathways implicated in other neurodegenerative disorders, including mitochondrial dysfunction, protein accumulation and the autophagic-lysosomal pathway....
متن کاملCytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy.
PINK1 is a mitochondrial kinase proposed to have a role in the pathogenesis of Parkinson's disease through the regulation of mitophagy. Here, we show that the PINK1 main cleavage product, PINK152, after being generated inside mitochondria, can exit these organelles and localize to the cytosol, where it is not only destined for degradation by the proteasome but binds to Parkin. The interaction o...
متن کاملPINK1- and Parkin-mediated mitophagy at a glance.
Seok Min Jin and Richard J. Youle* Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Center Drive, 10-5D37 Bethesda, MD USA *Author for correspondence ([email protected]) Journal of Cell Science 125, 795–799 © 2012. Published by The Company of Biologists Ltd doi:10.1242/jcs.093849 This article is part of a...
متن کاملLoss of iron triggers PINK1/Parkin-independent mitophagy
In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. Using this assay, we identify iron chelators as a family of compounds that generate a strong mitophagy response. Iron chelation-induced mitophagy requires that cells undergo glycolysis, but does not require PINK1...
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ژورنال
عنوان ژورنال: Trends in Neurosciences
سال: 2014
ISSN: 0166-2236
DOI: 10.1016/j.tins.2014.03.004